2026-06-22T19:25:25Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2389251619 2026-05-19T06:00:26.773Z

4.2 EI 10.15151/ESRF-ES-2389251619 Sophie Therese ANUTH Sophie Therese Anuth 0009-0005-3479-1984 Stefan MISCHLIWSKI Stefan Mischliwski Paul WEIGL Paul Weigl 0000-0001-7434-7988 Julie VILLANOVA Julie Villanova Sophie Therese ANUTH Sophie Therese Anuth 0009-0005-3479-1984 Enni MATTERN Enni Mattern 0009-0007-4112-0577 Bernhard HESSE Bernhard Hesse 0000-0001-9106-8980 Jussi-Petteri SUURONEN Jussi-Petteri Suuronen 0000-0002-1632-761X Stefan MISCHLIWSKI Stefan Mischliwski Bernhard HESSE Bernhard Hesse 0000-0001-9106-8980 Enni MATTERN Enni Mattern 0009-0007-4112-0577 Emely BORTEL Emely Bortel Emely BORTEL Emely Bortel Jussi-Petteri SUURONEN Jussi-Petteri Suuronen 0000-0002-1632-761X Example Institute 2029 Data from large facility measurement 2026-05-16T06:00:00Z/2026-05-19T06:00:00Z 2026-05-19T06:00:00Z I CC-BY-4.0 Single-tooth loss is often treated with implant-retained crowns. Conventional screw implants require invasive surgery, whereas root-analogue implants can be placed directly into extraction sockets. Yet, past attempts failed due to lacking a periodontal ligament (PDL) analogue, vital for physiological attachment. Our project (BMBF: BioPIZ) addresses this by creating a bionic replica of the tooth root surface via additive manufacturing and post-processing, enhanced with a 3D-bioprinted extracellular matrix layer to support periodontium regeneration. The proposed synchrotron nanoCT experiment will generate sub-micrometer 3D data of native cementum, providing the digital blueprint for a biomimetic implant surface. This approach aims to ensure physiological integration of BioPIZ implants and prevent complications such as peri-implantitis, bone resorption and mucositis, advancing dental implantology toward truly biomimetic, root-analogue solutions.