2026-06-27T22:50:01Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2376081641 2026-05-11T06:00:55.914Z

4.2 EI 10.15151/ESRF-ES-2376081641 Lejaine BOUZZINE Lejaine Bouzzine Stéphan PISSOT Stéphan Pissot 0000-0002-2025-7036 Helene ELLEAUME Helene Elleaume 0000-0002-3991-9503 Anne-Laure BULIN Anne-Laure Bulin 0000-0002-2644-8626 Barbara FAYARD Barbara Fayard Helene ELLEAUME Helene Elleaume 0000-0002-3991-9503 Meryem TAI Meryem Tai SARVENAZ KESHMIRI Sarvenaz Keshmiri Stefano CHECCHIA Stefano Checchia 0000-0003-0499-4885 Barbara FAYARD Barbara Fayard Jean Francois ADAM Jean Francois Adam Sébastien RIGOLLET Sébastien Rigollet 0009-0005-4638-4999 Marco DI MICHIEL Marco Di Michiel 0000-0002-1039-3579 SARVENAZ KESHMIRI Sarvenaz Keshmiri Jean Francois ADAM Jean Francois Adam Meryem TAI Meryem Tai Stéphan PISSOT Stéphan Pissot 0000-0002-2025-7036 Lejaine BOUZZINE Lejaine Bouzzine Marie D ALLEMAGNE Marie D Allemagne Jean Luc RAVANAT Jean Luc Ravanat 0000-0002-7123-6358 Sébastien RIGOLLET Sébastien Rigollet 0009-0005-4638-4999 Anne-Laure BULIN Anne-Laure Bulin 0000-0002-2644-8626 Marie D ALLEMAGNE Marie D Allemagne Jean Luc RAVANAT Jean Luc Ravanat 0000-0002-7123-6358 Example Institute 2029 Data from large facility measurement 2026-05-05T06:00:00Z/2026-05-11T06:00:00Z 2026-05-11T06:00:00Z I CC-BY-4.0 Glioblastoma (GBM) is the most common and aggressive primary tumour. Its prognosis is very poor, with survival ranging from 12-15 months. Due to the chemoresistance and highly infiltrative growth of GBM, current treatments can only slow the development of the disease. The main limit to the effectiveness of chemotherapies in the brain is their restricted access due to the presence of the blood brain barrier (BBB), which limits the passage of most drugs. Recently, focused ultrasound (FUS) in combination with microbubbles, has attracted attention as a non-invasive means of temporarily opening the blood-brain barrier (1). X-ray fluorescence (XRF) imaging is a powerful imaging technique for quantification of trace elements in biological samples. In this study, we propose use XRF to quantify platinum concentrations in the brains of F98 glioma-bearing rats after FUS-enhanced chemotherapy of carboplatin, in comparison to simple carboplatin intravenous injections.