2026-06-01T00:42:03Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2120430037 2025-06-01T06:00:18.633Z

4.2 EI 10.15151/ESRF-ES-2120430037 Manfred BURGHAMMER Manfred Burghammer Markus OSTERHOFF Markus Osterhoff 0000-0002-7865-515X Mangalika SINHA Mangalika Sinha Sarah KOESTER Sarah Koester 0000-0002-0009-1024 Markus OSTERHOFF Markus Osterhoff 0000-0002-7865-515X Mangalika SINHA Mangalika Sinha BORAM YU Boram Yu 0000-0002-0683-7026 BORAM YU Boram Yu 0000-0002-0683-7026 Rita MENDES DA SILVA Rita Mendes Da Silva 0000-0001-6455-3710 Rita MENDES DA SILVA Rita Mendes Da Silva 0000-0001-6455-3710 Example Institute 2028 Data from large facility measurement 2025-05-29T06:00:00Z/2025-06-01T06:00:00Z 2025-06-01T06:00:00Z I CC-BY-4.0 The aim of this project is to combine highly complementary imaging methods – i.e., scanning small angle x-ray scattering, fast bright field microscopy and visible light fluorescence microscopy - for the structure determination of components inside biological cells, in particular the cytoskeleton and the nucleus. Importantly, the planned setup will in the future be applicable to a multitude of different sample types, from biological to soft matter and hard condensed matter. Our focus for the upcoming three years will be on (i) model cell lines with a pronounced keratin network, and (ii) biologically relevant heart muscle cells with and without desmin mutants that cause cardiomyopathy. The setup shall be made available to the user community after set-up and commissioning.