2026-06-03T02:43:03Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2108131780 2025-05-13T06:02:04.844Z

4.2 EI 10.15151/ESRF-ES-2108131780 Xiaolu HE Xiaolu He Xiaolu HE Xiaolu He Hongye LI Hongye Li Guangzhen WANG Guangzhen Wang Hongye LI Hongye Li Guangzhen WANG Guangzhen Wang Sofia ROGERS RUIZ Sofia Rogers Ruiz 0009-0005-9922-6222 Diego PONTONI Diego Pontoni 0000-0001-9450-5269 Sofia ROGERS RUIZ Sofia Rogers Ruiz 0009-0005-9922-6222 Elena VENTURELLI Elena Venturelli Elena VENTURELLI Elena Venturelli Egor BERSENEV Egor Bersenev 0000-0001-5609-7794 Egor BERSENEV Egor Bersenev 0000-0001-5609-7794 Wuge H BRISCOE Wuge H Briscoe Wuge H BRISCOE Wuge H Briscoe Example Institute 2028 Data from large facility measurement 2025-05-10T06:00:00Z/2025-05-13T06:00:00Z 2025-05-13T06:00:00Z I CC-BY-4.0 U-RHYTHM, www.u-rhythm.co.uk, is a groundbreaking wearable diagnostic clinical research device at the Bristol Medical School that uses micro-dialysis to sample hormones directly from human interstitial fluid at closely-space intervals throughout the day and night, monitoring the dynamics of hundreds of metabolites and advancing the field of endocrinology[1]. However, ultra-hydrophobic sex hormones cannot be currently detected due to a combination of their low concentrations and their adsorption to the device tubing. Here, we propose a first comprehensive XRR study at the air-water interface to evaluate the F127 Langmuir monolayer structure due to molecular interactions between F127 monolayers and sex hormones with various molecular architectures (Fig. 1), at different surface pressures, temperatures and concentrations. Such fundamental insights from the model system will provide critical nanostructural evidence for the proposed mechanism for enabling enhanced capacity of the U-RHYTHM t