Biologically relevant silver-glutathione complexes. A XAS study to establish key structures responsible for toxicity and detoxication

2026-06-13T06:10:52Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2064077603 2025-04-29T08:11:02.211Z

4.2 EI 10.15151/ESRF-ES-2064077603 Isabelle KIEFFER Isabelle Kieffer 0000-0001-5406-6046 HESTER BLOMMAERT Hester Blommaert Wojciech BAL Wojciech Bal 0000-0003-3780-083X Aurelien DENIAUD Aurelien Deniaud Wojciech BAL Wojciech Bal 0000-0003-3780-083X Aurelien DENIAUD Aurelien Deniaud Giulia VERONESI Giulia Veronesi 0000-0001-9228-6082 Giulia VERONESI Giulia Veronesi 0000-0001-9228-6082 Paulina SZCZERBA Paulina Szczerba 0000-0003-3723-4735 Paulina SZCZERBA Paulina Szczerba 0000-0003-3723-4735 Biologically relevant silver-glutathione complexes. A XAS study to establish key structures responsible for toxicity and detoxication Example Institute 2028 Data from large facility measurement 2025-04-23T06:30:00Z/2025-04-28T06:00:00Z 2025-04-28T06:00:00Z I CC-BY-4.0 A comprehensive Ag K-edge XAS study of oligomeric and polymeric complexes formed by glutathione (GSH) and silver ions is proposed, to complement and provide structural edge to spectroscopic and spectrometric characterization of these complexes. The main issues to be solved are the mode of coordination of Ag (S only vs. S+O), the coordination number (2 vs. 2/3) and the formation of ring oligomers vs. infinite chain polymers. All three issues are fundamental to the understanding of formation of Ag/GSH complexes in cells upon the dissolution of toxic silver nanoparticles and their role in detoxication vs. toxicity of silver.