2026-06-03T14:25:35Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2051955633 2025-04-22T06:00:26.523Z

4.2 EI 10.15151/ESRF-ES-2051955633 Sylvain BOHIC Sylvain Bohic 0000-0001-6355-7592 Joelle SOBCZAK Joelle Sobczak 0000-0001-7180-2789 Joelle SOBCZAK Joelle Sobczak 0000-0001-7180-2789 Michele SALMAIN Michele Salmain 0000-0003-3039-5659 Michele SALMAIN Michele Salmain 0000-0003-3039-5659 Tom LACOMA Tom Lacoma 0009-0007-0501-3213 Tom LACOMA Tom Lacoma 0009-0007-0501-3213 BENOIT BERTRAND Benoit Bertrand 0000-0003-0542-4454 BENOIT BERTRAND Benoit Bertrand 0000-0003-0542-4454 Example Institute 2028 Data from large facility measurement 2025-04-17T06:00:00Z/2025-04-22T06:00:00Z 2025-04-22T06:00:00Z I CC-BY-4.0 A wide range of molecular gold compounds display cytotoxic properties and may in turn provide safer and more efficient alternatives to clinically approved platinum based anticancer drugs. In this context, structure-activity relationship studies we performed on an array of cationic biphenyl gold(III) complexes with a carbene-pyridine chelating ligand showed a marked dependence of both the antiproliferative property and the chemical reactivity on the nature of the C^N ligand. We now wish to examine by nano-XRF the impact of the C^N ligand of 3 representative gold complexes on the distribution and concentration of gold in cancer cells shortly exposed to each of these complexes at biologically meaningful concentration. Correlative fluorescence microscopy of cellular organelles with multicolour staining dyes will warrant precise location of gold and other heavy elements in cryo-fixed cancer cells