2026-06-01T17:11:30Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2036722611 2025-05-02T08:57:16.945Z

4.2 EI 10.15151/ESRF-ES-2036722611 Paul TAFFOREAU Paul Tafforeau 0000-0002-5962-1683 Theresa URBAN Theresa Urban 0000-0002-0352-8180 Theresa URBAN Theresa Urban 0000-0002-0352-8180 Dai CHEN Dai Chen Dai CHEN Dai Chen Joseph BRUNET Joseph Brunet 0000-0002-8424-9510 Hector DEJEA I VELARDO Hector Dejea I Velardo 0000-0003-2584-9812 Joseph BRUNET Joseph Brunet 0000-0002-8424-9510 Edoardo OCCHIPINTI Edoardo Occhipinti 0000-0003-4691-9007 Edoardo OCCHIPINTI Edoardo Occhipinti 0000-0003-4691-9007 Peter D LEE Peter Lee 0000-0002-3898-8881 Peter D LEE Peter Lee 0000-0002-3898-8881 Andrew KEENLYSIDE Andrew Keenlyside 0000-0002-6059-2103 Andrew KEENLYSIDE Andrew Keenlyside 0000-0002-6059-2103 Example Institute 2028 Data from large facility measurement 2025-04-30T06:00:00Z/2025-05-02T06:00:00Z 2025-05-02T06:00:00Z I CC-BY-4.0 Humans and other large organisms are three-dimensional multiscale biological systems where large scale function and structure are dependent on the macrostructure’s interconnectivity down to the cellular and subcellular level. Using the exceptional coherence provided by the ESRF-EBS, we have demonstrated that propagation-based phase-contrast can effectively decouple resolution from specimen size in soft tissue, obtaining 1.4 micron voxel resolution in 150 mm diameter human organs. Through this Long Term Proposal (LTP) we will develop the techniques required to image whole human and animal bodies ex vivo at 25 micron resolution, zooming to sub-micron voxels (0.7micron) locally, resolving sub-cellular structures through hard- and soft-tissue. Resolving how the micro (sub-cellular) interacts with the macro (whole organism) across length scales will provide all new insights into biological and biomedical function. This is true for both healthy and pathological system level behaviour.