Coordinated user access to HTX lab – MASSIF-1 facilities for fragment screening and new structures. With funding through iNEXT Discovery, In

2026-06-03T19:34:50Z https://icatplus.esrf.fr/oaipmh/request

oai:icatplus.esrf.fr:inv/2019967176 2025-04-25T06:00:15.380Z

4.2 EI 10.15151/ESRF-ES-2019967176 SIHYUN SUNG Sihyun Sung 0000-0001-5820-4696 SIHYUN SUNG Sihyun Sung 0000-0001-5820-4696 Jose Antonio MARQUEZ Jose-Antonio Marquez 0000-0002-3453-9261 Andrew MCCARTHY Andrew Mc Carthy 0000-0003-4478-0136 Rosicler BARBOSA Rosicler Barbosa Rosicler BARBOSA Rosicler Barbosa Coordinated user access to HTX lab – MASSIF-1 facilities for fragment screening and new structures. With funding through iNEXT Discovery, In Example Institute 2028 Data from large facility measurement 2025-04-24T07:30:00Z/2025-04-25T06:00:00Z 2025-04-25T06:00:00Z I CC-BY-4.0 This proposal will provide user access to automated protein-to-structure and fragment screening pipelines based on the combination of EMBL HTX lab services and CrystalDirect technology and automated data collection at ESRF’s MX beamlines, within the framework of the EMBL-ESRF JSBG agreement. The access will encompass three key services: 1) Online-Crystallography for Protein-to-Structure analysis, 2) High throughput ligand and Fragment Screening, and 3) innovative Plate-to-beam data collection techniques, made possible by CrystalDirect’s integration at ESRF’s MASSIF1 beamline. Access will be granted through competitive, peer review, as part of EC-funded iNEXT, ISIDORE, CNASERV and Instruct-ERIC consortia. The proposal includes development of new methods to expand the experimental capabilities to perform cutting-edge research in structural biology through furhter integration of CrystalDirect at MASSIF-1 within the framework of international collaborations.